Sunday, May 4, 2014

UPMC Children's Hospital

It’s been a while since I’ve updated you all.  I’ve found that the second year, although less stressful, is still quite busy.  With moving around from site to site, studying for the monthly exams, job hunting, and working full-time I’ve found that I haven’t had as much time to blog as I would like.

Tomorrow will be the start of my third week at UPMC Children’s Hospital in Pittsburgh, PA.  Like the name suggests, Children’s Hospital is dedicated to the care of infants, children, and young adults. Their services include ENT, emergency medicine, childhood cancer, transplant programs, and much more. The world of pediatric pathology is quite different than adult pathology; therefore this rotation site is an invaluable experience.

Children's is primarily a surgical pathology rotation, but there are occasionally autopsy cases. The Pathology Department has three amazing pathologists’ assistants who work with you at the grossing bench.This rotation gives you the opportunity to gain experience with the pathologies that are more common in children than adults. Some of the classic cases include: congenital heart malformation, Hirschsprung’s disease, bone cancer (ex- osteosarcoma, Ewing’s sarcoma), Wilms’ tumor, rhabdomyosarcoma, neuroblastoma, and leukemia.  

Normal position of heart and lungs.
A cartoon of a congenital condition, situs inversus, where the
major visceral organs are a mirror image of their normal positions.
Typically these people can live "normal" healthy lives - the body is amazing!

Monday, April 14, 2014

Happy 1st Annual Pathologists’ Assistant Day

Since today is the 1st Annual Pathologists’ Assistant Day, I wanted to ensure that everyone knew what was being celebrated! If you’re still confused as to what exactly a Pathologists’ Assistant is, I’ve answered a few frequently asked questions below.

What is pathology?
Pathology simply means the study of disease.  Pathology focuses on the four components of disease: the cause, the mechanisms of development, the structural alterations of cells, and the clinical manifestations (why you go see a doctor).  Pathology can be further subdivided into anatomical pathology and clinical pathology. Anatomical pathology regards the diagnosis of disease based on the gross, microscopic, chemical, immunologic, and molecular examination of organs, tissues, and whole bodies. Clinical pathology focuses on the use of laboratory analysis of body fluids to diagnose disease.

What is a Pathologists’ Assistant?
A Pathologists’ Assistant is a trained healthcare professional who works under a pathologist.  Just like a Physician’s Assistant assists the physicians with their services; Pathologists’ Assistants work in a similar way by assisting Pathologists with their services.  The majority of the PA's work encompasses the anatomical pathology subdivision; they are responsible for the gross examination of organs, tissues, and bodies. They prepare tissue for pathologic testing and examination under the microscope.

What is the difference between a Pathologist and a Pathologists’ Assistant?
A Pathologist is a physician who has completed medical school and residency. Pathologists make diagnoses based upon the gross examination and tissue prepared by the PA.  PAs do not go to medical school and complete crucial steps necessary for the pathologist to make diagnoses, but cannot sign out reports or make diagnoses.

How often do PAs use microscopes?
As I mentioned earlier, the PA's duties focus mostly on the gross examination of specimens, examination with the naked eye. The microscopic examination is left to the Pathologists.  For schooling and board purposes, PAs are required to have an understanding of histology and should be able to identify normal versus abnormal tissue under the microscope.

What kind of jobs can you have as a Pathologists’ Assistant?
As a PA you can work in academic and community hospitals, medical examiners offices/morgues, private laboratories, etc.

What kind of work do PAs do in hospitals?
Anatomical pathology can be further divided into surgical pathology and autopsy pathology.  Most people are familiar with autopsy pathology, but not as familiar with surgical pathology.  Every time something gets removed during surgery, the specimen is sent to the surgical pathology laboratory.  These specimens range from GI biopsies and gallbladders to leg amputations and lungs (and everything in between).  It’s the PA’s job to examine the tissue or organ and write a detailed description for the pathologist.  Then the PA will submit certain tissues for further testing and examination (frozen section analysis, flow cytometry, immunohistochemistry, etc.).  The Pathologist will then be able to make a diagnosis based on the gross description, microscopic evaluation, and any further testing.

What kind of training is needed to become a Pathologists’ Assistant?
The majority of the accredited Pathologists’ Assistant programs are two-year programs culminating in a Master's Degree in Health Science.  Currently there are 9 NAACLS (National Accrediting Agency for Clinical Laboratory Sciences) accredited Pathologists’ Assistant programs: Drexel University, Duke University, Indiana University, Quinnipiac University, Rosalind Franklin University, University of Maryland, University of Western Ontario, Wayne State University, and West Virginia University.  Typically the programs consist of one didactic year followed by a year of clinical training. After graduating from a PA program, Pathologists’ Assistants can choose to take the American Society for Clinical Pathology’s (ASCP) Board certification exam to become ASCP certified.

What do you like most about being a Pathologists’ Assistant?
I love that each day at work is completely different; you never know what you’re going to see at your grossing station or autopsy table. You’re constantly challenged and sometimes have to get creative with how you’re going to process complex specimens.


I want to wish a very happy Pathologists’ Assistant Day to all the current and future PAs; keep doing amazing work!






Monday, April 7, 2014

St. Francis Hospital

My six-week autopsy rotation has come and gone and I’ve started my new rotation at St. Francis Hospital.  St. Francis is a community-based hospital in Charleston, WV. It’s a smaller hospital and the Pathology Department is comprised of one pathologist, three histotechnologists, and one transcriptionist.  Since it’s a smaller hospital and there is a lighter specimen load, the PA students get to do all of the grossing. 

A typical workday at St. Francis starts by reviewing the slides, under the microscope, from the previous day with the pathologist.  I really value this time because it allows me to get immediate feedback on the sections I submitted and find out if anything was missing from my dictations. Once the pathologist has signed out the cases, I head to the gross room and start grossing the specimens for the day.  St. Francis seems to get a lot of head and neck specimens (tonsils, thyroid, parotid gland, etc.) as well as skins, GI biopsies, and occasionally colons. Occasionally, the pathologist does get called for frozen sections, so I’ve been able to get more practice cutting frozen sections as well.

I really enjoy the fact that this rotation allows you to work independently and make your own judgment calls.  I'm starting to feel confident that I know what sections to take and the pertinent information to include in the dictations.  It feels good not to be asking nearly as many questions!

So many tonsils!





Sunday, March 16, 2014

10 Autopsy FAQs

It’s hard to believe that we are starting the 5th week of the autopsy rotation. I’ve come a long way since the first body I eviscerated. My hands and muscles have developed motor memory and I feel much more confident in my evisceration skills.  During these last few weeks our goal is to pick up speed (my personal record for complete evisceration and head dissection is about 2 hours); we know what to cut, it’s just a matter of not wasting time and second guessing ourselves.


For this post I thought I’d answer some frequently asked questions about the autopsy process:

What kinds of deaths require an autopsy?
  • Violent deaths (accidents, suicides, and homicides)
  • Suspicious deaths
  • Sudden and unexpected deaths
  • Unattended deaths (physician is not in attendance and can't sign the death certificate)
  • Deaths in custody
  • Consented hospital deaths

Is there some sort of permission for an autopsy to be done?
The first step of any autopsy is making sure that you have the right paperwork and consent for the body. Hospital autopsies require the consent of next of kin or the medical power of attorney.  However, most U.S. jurisdictions do not require consent for medicolegal autopsies.

What is the purpose of an autopsy?
  • For hospital cases: to confirm a suspected cause of death, for teaching purposes, or to assess effectiveness of a treatment
  • For medicolegal cases: to determine the cause and manner of death, collect trace evidence from the bodies in criminally related cases, and to positively identify a body

What are some examples of causes of death?
The cause of death is defined as “the underlying disease or injury that begins the pathophysiological train of events that culminates in the electrical silence of the heart and brain”1. Examples of cause of death include gunshot wound to the head, atherosclerotic coronary artery disease, carcinoma of the pancreas, pulmonary embolism, etc.

Are all autopsies completed the same way?
Most autopsies, on adults and children, are completed by making the “Y incision” - an incision from the left and right acromion process (shoulders), which meet at the xiphoid process of the sternum, and is continued down the torso to the pubic bone. After the Y incision is made, the skin and soft tissues are reflected and the chest plate is removed.  This allows for the organs to be viewed and subsequently removed. Typically the autopsy also consists of dissection of the head and neck. If there is suspected pathology (ex. deep vein thrombosis) or identifying material (ex. serial number on hip replacement hardware) in the limbs, a limb dissection can be completed as well.
However, in hospital autopsy cases the extent of the autopsy may be limited based on the next of kin’s request.  For example, the next of kin could request brain and lungs only, which means that we cannot eviscerate any of the other organs.  

Are all the cases like the ones I’ve seen on CSI shows?
In real life, autopsies take way longer than 10 minutes and the cause of death isn’t always clear-cut and doesn’t get stated with a background of dramatic music. In West Virginia the majority of the medical examiner cases are drug overdoses; these bodies look essentially “normal”. The autopsy doesn’t reveal much and the pathologist will have to wait for the toxicology screen to come back before determining cause of death.  Occasionally, you do see some weird and interesting things that may be television worthy.

How quickly does the autopsy get done?
The time it takes to complete an autopsy varies from case to case. The fastest I’ve seen one done has been one hour and the longest being around six hours.  I’d say on average they tend to take about 2-3 hours.

Doesn't the smell bother you?
Personally, the smell doesn’t bother me too much, but I also try not to consciously think about it.  Olfaction is a quickly adapting sense; our receptors adapt so that the system can respond to new odors despite old odors still being present.  You wouldn’t want your nose to be hung up on the smell of dead body and miss the smell of smoke from a nearby fire.  Therefore, the smell may get to you for a couple of seconds, but then you’ll be used to it and carry on as normal.

However, does opening the bowel smell pretty terrible? – yes (such a glamorous lifestyle- taking poop out of a bowel). And can you sometimes figure out the decedent’s last meal by smelling the stomach contents? – yes and it’s revolting. Luckily, in West Virginia, the decomposed bodies (which smell way worse than freshly deceased bodies) go to the OCME in Charleston, WV, so we typically don’t have to work with the really smelly ones.

What happens to the organs when they are removed? Do people get buried with them?
Once the organs are removed from the body, we section through them to look for any tumors, lesions, pathology, etc.  A piece from each organ is put in a save jar so that the pathologist is able to go back to them later if needed.  We also submit histologic sections from particular organs or any pathology present so that the pathologist can evaluate the organs on a microscopic level.  Whatever we don’t save or submit as histologic sections is packaged up with the body and gets buried/cremated with the decedent.

How many autopsies are you doing in a day? What do you do when there aren’t any autopsies to be done?
At WVUH’s autopsy suite there are two autopsy tables, so two cases can be worked on simultaneously.  The most autopsies we’ve ever done in a day (9am-5pm) was six.  On average I’d say we usually do 2-3 per day.  Whenever there aren’t autopsies we stay on-site and study or work on any autopsy reports until 2:30pm or a body comes in (whichever is first).



1Guidelines for Reports by Autopsy Pathologists, Vernard I. Adams, 2010.

Sunday, February 23, 2014

Tissue Bank and Autopsy Rotations

Life has been pretty busy since I finished my last rotation and started the next one. I’ve moved back to Morgantown for the next 6 weeks, created a CV and started looking for jobs, prepared a 30 minute presentation for this Friday, and our monthly test is coming up so I’ve been increasing my study time.

Tissue Bank Rotation:
From February 10-14th I was at the University of Pittsburgh HSC Tissue Bank (located in UPMC Shadyside Hospital).  Tissue banks serve as reservoirs of tissue/samples for researchers to use. These samples can come in the form of tissues from certain organs, tumor cells, blood, etc.  A researcher may want to use these samples to test out new therapies, perform molecular studies, or track specific data.

The employees of the tissue bank act as “honest brokers” between the researcher and the patient/sample collected. They de-identify the patient’s tissue and assign it an anonymous number; therefore the researcher never has patient information on the tissue that they’re working on.

A researcher can’t just take any and every tissue they want; they have to have approval from the Institutional Review Board (IRB) first.  The IRB is a committee that monitors biomedical and behavioral research involving humans and serves to protect patient rights and minimize risk. In addition to IRB approval, some sample types (ex-blood) require consent from the patient as well.  Therefore the patient can be reassured that their diagnosis and care comes before any research.

How does all this apply to Pathologists’ Assistants? Pathologists' Assisstants can work for and manage tissue banks. Also it’s great to have knowledge of tissue banking procedures so that when working in the surgical gross room, you will know what to do with a bankable specimen if it comes across your grossing bench.

This is a really simplistic overview, but I hope it gives you an understanding of what the tissue bank entails!


WVUH Autopsy Rotation:

This past week I started my new rotation at the WVUH autopsy suite. It wasn’t too busy this week, which was great because it allowed myself and the other student to dive right in and start eviscerating.  It has been a big change going from surgical pathology to autopsy pathology. Not everything has to be “museum perfect” for autopsy pathology.  I don’t know how many times I was told this week to stop using the surgeon tools and pick up the long butcher knife (don’t worry I’m not hacking away at things as much as this statement makes it seem).  I’m slowly but surely getting a little less awkward with the tools, recovering my anatomy knowledge, and becoming more comfortable with eviscerating.